Тромбоцитарная агрегация. Механизм участия адгезивных молекул и митохондрий

В.Т. Чещевик (V.T. Cheshchevik), Д.В. Жерносеков (D.D.Zhernossekov)

Аннотация


В статье представлены основные механизмы агрегации тромбоцитов с участием адгезивных молекул, раскрыта регулирующая роль митохондрий при агрегации тромбоцитов и в тромбообразовании. Выявлены основные молекулярные и клеточные мишени терапевтического воздействия при патологическом тромбообразовании. Ключевые слова: тромбоциты, митохондрии, адгезивные молекулы, интегрин, факторы свертывания крови, плазминоген, поры высокой проницаемости. The role of mitochondria and adhesive molecules in the platelet aggregation and the thrombus formation is presented. The membrane permeability transition and integrin α IIb β3 were determined as a key target of treatment in cells at various pathological states associated with the thrombus formation. Keywords: platelets, mitochondria, adhesive molecules, integrin, coagulation factors, plasminogen, membrane permeability transition pores.

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