Effect of triterpenoid betulin on expression of carnitine-palmitoyltransferase-i in liver of rats with non-alcoholic fatty liver disease with signs of steatohepatitis
Keywords:
betulin, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, carnitine palmitoyltransferase 1, lipid metabolismAbstract
The present study was the first to demonstrate that betulin increases both the expression and enzymatic function of carnitine palmitoyltransferase type 1 (CPT-1) in liver tissue during experimental non-alcoholic fatty liver disease, as determined by the use of certain steatohepatitis markers in rat models. This increase in CPT-1 correlated with an increase in mitochondrial β-oxidation of fatty acids, culminating in a reduction in the severity of steatohepatosis and dyslipidemia symptoms. This finding significantly expands the understanding of the molecular mechanisms underlying the lipid-lowering properties of betulin and its potential application as a therapeutic agent for non-alcoholic fatty liver disease.
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