D-panthenol modulation of microelement balance in blood circulation in acute cerebral ischemia in white rats
Keywords:
cerebral ischemia, blood, panthenol, microelements, inductively coupled plasma mass spectrometryAbstract
The balance of micronutrients in the body is closely linked to the formation of the metalloproteome, which is disrupted during ischemia of the CNS. The research of the effect of D-panthenol, which has anti-ischemic activity, is of interest for experimental and clinical neurology.
Aim of the study. To study the trace element status of peripheral blood in a simulated state of acute ischemia of the central nervous system.
Materials and Methods. The elemental composition of peripheral blood (whole blood and plasma) of male rats subjected to surgical bilateral ligation of the carotid arteries for 2 h was studied using inductively coupled plasma mass spectrometry. D-panthenol (200 mg/kg) and its composition with nanoforms of Fe, Se, and Zn were administered as protectors for 3 days prior to surgery.
Results. The results revealed an imbalance in elemental status in the operated animals, with opposing changes in Mg, Cr, Fe, and Co and a decrease in Mn in whole blood, as well as a decrease in Cr and an increase in Se in plasma.
Conclusion. Changes in microelement status were partially corrected by the administration of the CoA precursor, D-panthenol, indicating a metabolic link between coenzyme biosynthesis and the formation of a metalloproteome response in acute ischemic damage to the central nervous system.
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