Role of mitochonrion membrane potential and reactive oxygen species in platelet aggregation
Keywords:
platelets, aggregation, mitochondrial potential, reactive oxygen species, apoptosisAbstract
This article presents data on the role of membrane potential and reactive oxygen species in agonist-induced platelet aggregation. We found a decrease in membrane potential upon inhibition of the mitochondrial respiratory chain, demonstrating the complex role of mitochondria in platelet aggregation. It was also found that respiratory chain inhibition during the initial stages of platelet activation results in a sudden increase in reactive oxygen species, which levels off over time, suggesting a regulatory role for reactive oxygen species in platelet aggregation.
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