Screening of biochemical composition and integral antiradical activity of begoniaceae representatives
Ключевые слова:
Begoniaceae, secondary metabolic substances, antiradical activity, coulometric titration, electrochemistryАннотация
Objective of the study is to evaluate the integral antiradical activity (hereinafter referred to as IAA) and conduct biochemical screening of the content of biologically active compounds in representatives of Begoniaceae.
Materials and methods. Standard methods of biochemistry and electrochemistry used.
Results. IAA was evaluated and biochemical screening of the content of biologically active compounds (flavonols, anthocyans, catechins, ascorbic acid, hydrophilic pectin and protopectin) of eight representatives of the Begoniaceae family was performed. The prospects of using such an indicator as IAA for screening plant materials in order to expand the range of medicinal plants is shown, which indicates the need for research in the field of antiradical properties and biochemical composition of medicinal plants, herbal preparations and biologically active additives of plant origin.
Conclusion. IAA and the obtained data on the content of biologically active compounds are a comprehensive indicator of the quality of plant materials and can be successfully used to standardize it. The introduction of a test for IAA in the future may allow to: quickly and accurately assess the quality of the used plant materials of the Begoniaceae family; make multicomponent preparations with a given antioxidant activity; expand the indications for the use of drugs and determine the most selective solvent for the extraction of active substances from plant material.
Библиографические ссылки
References
Schiller Е., Kriz W., Bartsch H. Free Radicals and Inhalation Pathology. Berlin, Springer, 2004. 773 p.
Halliwell B., Gutteridge J. Free Radicals in Biology and Medicine. Oxford, Oxford University Press, 2007. 704 p.
Kelvin J.A. Free Radicals Biology & Medicine. Oxford, Oxford University Press, 2007. 177 р.
Cadenas E., Packer L., Poli G. Free Radicals in Brain Pathophysiology. Boca Raton, CRC Press, 2000. 645 p.
Ozben T. Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Significance. Berlin, Springer, 1998. 395 р.
Grune T. Free Radicals And Diseases: gene expression, cellular metabolism and pathophysiology. Amsterdam, IOS Press, 2005. 193 р.
Antioxidant activity of Cordyceps-based preparations. Green Pharmacy, 2007. (In Russian). Available at: http://www.medeor.ru/antiocsidantcordirezultat.htm (accessed 12.10.2007).
Asaho Т. Various pathogenetic factors revolving around the central role of protein kinase С activation in the occurrence of cerebral vasospasm. Critical Rev. in Neurosurgery, 1998, V. 1, no 3, pp. 176-187.
Berberova N.T. From the life of free radicals. Soros Educational Jour¬nal, 2000, V. 6, no. 5. P. 34. (In Russian)
Shakhova, G.I. Begonias. Moscow. 2006. 126 p. (In Russian)
Sheryakova A.A. State Pharmacopoeia of the Republic of Belarus. Quality control of excipients and medicinal plant raw materials. Molodechno, Printing house "Pobeda" 2008. V. 2. P. 309-310. (In Russian)
Godovalnikov G.V. State Pharmacopoeia of the Re¬public of Belarus. General methods of medicines quality control. Minsk, Minsk State Vocational College of Typography, 2006. V. 1. P. 630. (In Russian)
Abdulin I.F. Materials of the II All-Russian Conference: Chemistry and Technology of Plant Substances, 2002, pp. 77-78. (In Russian)
Turova E.Ya. Materials of the Volga conference on analytical chemistry. Kazan, 2001, pp. 77-78. (In Russian)
Ermakov, A.I. Methods of biochemical study of pla¬nts. Minsk, Minsk State Vocational College of Typography, 1987, pp. 90-91, 113-115, 158-160. (In Russian)
Godovalnikov G.V. State Pharmacopoeia of the Re¬public of Belarus. General methods of medicines quality control. Minsk, Minsk State Vocational College of Typography, 2006. V. 1. pp. 516-538. (In Russian)
Muravyeva D.A. Pharmacognosy. Moscow, Medicine, 1978, pp. 530-620, 569, 579-581. (In Russian)
Anisimov A.A. Basics of biochemistry. Moscow, Higher school, 1986, pp. 487–489. (In Russian)
Список литературы
Schiller, Е. Free Radicals and Inhalation Pathology / E. Schiller, W. Kriz, H. Bartsch. – Berlin: Springer, 2004. – 773 p.
Halliwell, B. Free Radicals in Biology and Medicine / B. Hall-iwell, J. Gutteridge. – Oxford: Oxford University Press, 2007. –704 p.
Kelvin, J A. Free Radicals Biology & Medicine / J.A. Kelvin. – Oxford: Oxford University Press, 2007. – 177 p.
Cadenas, E. Free Radicals in Brain Pathophysiology / E. Ca-denas, L. Packer G. Poli. – Boca Raton: CRC Press, 2000. – 645 p.
Ozben, T Free Radicals, Oxidative Stress, and Antioxidants: Pathological and Physiological Significance / T. Ozben. – Berlin: Springer, 1998. – 395 p.
Grune, T Free Radicals And Diseases: gene expression, cellular metabolism and pathophysiology / T. Grune. – Amsterdam: IOS Press, 2005. - 193 p.
Антиоксидантная активность препаратов на основе Корди-цепса. 2007. – Режим доступа: http://www.medeor.ru/antiocsidantcordirezultat.htm. – Дата доступа 12.10.2007.
Asaho, Т. Various pathogenetic factors revolving around the central role of protein kinase С activation in the occurrence of cerebral vasospasm / T. Asaho // Critical Rev. in Neurosurgery. – 1998. – Vol. 8, № 3. – pp. 176-187.
Берберова, H. T Из жизни свободных радикалов / Н. Т. Берберова // Соросовский образовательный журнал. – 2000. – № 5. – Т. 6. – С. 34.
Шахова, Г.И. Бегонии / Г.И. Шахова. – М., 2006. – 126 с.
Шерякова, А. А. Государственная фармакопея Республики Беларусь. Контроль качества вспомогательных веществ и лекарственного растительного сырья / А. А. Шерякова. – Молодечно: Типография «Победа», 2008. – Т. 2. – С. 309-310.
Годовальников, Г.В. Государственная фармакопея Рес¬публики Беларусь. Общие методы контроля качества лекарственных средств / Г. В. Годовальников. – Минск: Минский государственный ПТК полиграфии. 2006. – Т. 1. – С. 630.
Абдулин, И. Ф. Материалы II всероссийской конференции: Химия и технология растительных веществ. – Казань, 2002. – С. 77-78.
Турова, Е. Я. Материалы поволжской конференции по аналитической химии / Е. Я. Турова. – Казань, 2001. – С. 77-78.
Ермаков, А. И. Методы биохимического исследования рас¬тений / А. И. Ермаков. – Минск: Минский государственный ПТК полиграфии, 1987. – С. 90–91, 113–115, 158–160.
Годовальников, Г. В. Государственная фармакопея Республики Беларусь. Общие методы контроля качества лекарственных средств / Г.В. Годовальников. – Минск: Минский государственный ПТК полиграфии, 2006. – Т. 1. – С. 516-538.
Муравьева, Д. А. Фармакогнозия / Д. А. Муравьева. – М.: Медицина, 1978. – С. 530–620, 569, 579–581.
Анисимов, А. А. Основы биохимии / А. А. Анисимов, и др. – М.: Высшая школа, 1986. – С. 487-489.
