Physico-chemical and biological properties of chitosan and its application in the treatment of chronic dermatoses
Keywords:
chitosan, biopolymer, chronic dermatoses, clinical trials, mechanisms of action, biochemical markers, SCORAD, preventive therapyAbstract
The article presents a comprehensive analysis of the physico-chemical and biological properties of the natural biopolymer chitosan,as well as a detailed assessment of its therapeutic potential in the treatment of chronic dermatological diseases. Based on the results of a clinical study, the key mechanisms of chitosan's action are examined in detail: anti-inflammatory, immunomodulatory, regenerative, antimicrobial, and metabolic. The article includes statistical data processing. The pathogenetic basis of chitosan's efficacy and the prospects for preventive therapy of chronic dermatoses are discussed.
References
Список использованных источников
Бакулин, А. В. Физико-химические харак-теристики хитозан-меланиновых комплек-сов/ А. В. Бакулин, В. П. Курченко, Н. В. Сушинская, И. И. Азарко. – Том 4. Часть2. – М. : Центр«Биоинженерия» РАН; Мн. : БГУ, 2009. –9 с.
Намазова-Баранова, Л. С. Витамины и ми-неральные вещества в практике педиатра/ Л. С. Намазова-Баранова, С. Г. Макарова, В. М. Студеникин. – М. : ПедиатрЪ, 2016. – 299 с.
Эйзлер, А. К. Европейское исследование: БАДы, витамины, ГМО, биопродукты: как сделать правильный шаг к здоровому долголетию/ А. К. Эйзлер. – М. : Эксмо, 2016. – 431 c.
Клинический протокол«Диагностика и лечение пациентов(взрослое население) с папулосквамозными нарушениями». Утвержден Постановлением Министерства здравоохранения Республики Беларусь от 22.06.2024 №59.
Mohamed, S. H. Chitosan: A Natural Biopol- ymer with Versatile Applications / S. H. Mohamed, M. H. El-Rafie // Journal of Chemical and Pharmaceutical Research. – 2015. – Vol. 7(6). – P. 437-448.
Muzzarelli, R. A. A. Chitins and chitosans as immunoadjuvants and non-allergenic drug
carriers / R. A. A. Muzzarelli // Marine Drugs. – 2010. – Vol. 8(2). – P. 292-312.
References
Bakulin A.V., Kurchenko V.P., Sushinskaya N.V., Azarko I.I. Fiziko-khimicheskie kharakteristiki khitozanmelaninovy`kh kompleksov[Physico-chemical characteristics of chitosan-melanin complexes]. Moscow, Center «Bioengineering» RAS, Minsk, BSU, 2009, Vol. 4, part 2, 9 p. (In Russian)
Namazova-Baranova L.S., S.G. Makarova, V. M. Studenikin Vitaminy` i mineral`ny`e veshhestva v praktike pediatra[Vitamins and minerals in pediatric practice]. Moscow, Pediatr, 2016, 299 p. (In Russian)
Eizler A. K. Evropejskoe issledovanie: BADy`, vitaminy`, GMO, bioprodukty` : kak sdelat` pravil`ny`j shag k zdorovomu dolgoletiyu[European study: Dietary supplements, vitamins, GMOs, bioproducts: How to make the right step towards healthy longevity]. Moscow, Eksmo, 2016, 431 p. (In Russian)
Clinical protocol "Diagnosis and treatment of patients (adult population) with papulosquamous disorders". Approved by Decree of the Ministry of Health of the Republic of Belarus No. 59 dated June 22, 2024.
Mohamed S.H., El-Rafie M. H. Chitosan: A Natural Biopolymer with Versatile Applications. Journal of Chemical and Pharmaceutical Research. 2015. Vol. 7(6), pp. 437–448.
Muzzarelli R. A. A. Chitins and chitosans as immunoadjuvants and non-allergenic drug carriers. Marine Drugs. 2010. Vol. 8(2), pp. 292–312.






