Эволюция NO-синтазы в прокариотах и эукариотах: структурная организация и функциональная диверсификация

V.I. Dunai; A.S. Gubeyko

Authors

V.I. Dunai Polessky State University, Pinsk, Republic of Belarus
A.S. Gubeyko Polessky State University, Pinsk, Republic of Belarus

Keywords:

Nitric oxide synthase, prokaryotes, eukaryotes, genomic analysis

Abstract

Based on a comprehensive analysis of current literature, this review systematizes data on the evolution of nitric oxide synthase (NOS) from prokaryotic forms to specialized eukaryotic isoforms. It demonstrates that, as biological systems became more complex, NOS underwent significant structural and functional modifications, transforming from a nonspecific protective enzyme into a multifunctional regulator involved in neuro-signaling, vascular regulation, and immune modulation.

Author Biographies

V.I. Dunai, Polessky State University, Pinsk, Republic of Belarus

PhD in Biol. Sc., Associate Professor

A.S. Gubeyko, Polessky State University, Pinsk, Republic of Belarus

Graduate Student

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