Эволюция NO-синтазы в прокариотах и эукариотах: структурная организация и функциональная диверсификация
Ключевые слова:
NO-синтаза, прокариоты, эукариоты, геномный анализАннотация
На основе комплексного анализа современных литературных источников обзор систематизирует данные об эволюции NO-синтазы (NOS) от прокариотических форм к специализированным эукариотическим изоформам. Показано, что по мере усложнения биологических систем NOS претерпела существенные структурные и функциональные модификации, трансформировавшись из неспецифического защитного фермента в многофункциональный регулятор, участвующий в нейросигналинге, сосудистой регуляции и иммунной модуляции.
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