POLYMORPHISM OF R577X GENE ACTN3 IN BELARUSIAN SPORTSMEN SPECIALIZING IN GAME SPORTS
Keywords:
physical qualities, genetic markers, genotype, α-Actinin-3 gene, allele, polymorphism of restriction fragments, polymerase chain reactionAbstract
The article is devoted to the investigation of the role of gene encoding for the alpha-actinin-3 protein in the fast-twitch fibres (type II). The focus is on presenting the association between polymorphism R577X in the ACTN3 and display of muscular strength and power. The functional R-allele of the alpha-actinin-3 gene has been reported to get into elite sprint/power athlete status. The aim of the study is to determine the frequency distribution of ACTN3 genotypes and alleles in playing games. 219 individuals were composed two groups of the study: 109 professional elite athletes of playing sports and 110 individuals of control group. Genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism method. Exceptions of the distribution of genotypes and alleles of the genetic polymorphism have been revealed in elite athletes of playing sports. In conclusion, researchers are able to use this polymorphism as genetic marker of speed and strength qualities.
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